Monday, September 29, 2008

Reye syndrome

  1. characterized by acute noninflammatory encephalopathy and hepatic failure
  2. the etiology of Reye syndrome is unknown , occurs after a viral illness, particularly an upper respiratory tract infection (URTI), influenza, varicella, or gastroenteritis, and it is associated with the use of aspirin during the illness.
  3. more than 3-fold increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and/or ammonia levels
  4. Inborn errors that may mimic Reye syndrome include fatty-acid oxidation defects, amino and organic acidopathies, urea-cycle defects, and disorders of carbohydrate metabolism
  5. Reye syndrome is equally distributed between the sexes.
  6. Reye syndrome rarely occurs in newborns or in children older than 18 years
  7. Reye syndrome can occur after vaccination with live viral vaccines.
  8. Clinical features : pernicious vomiting Lethargy Diarrhea and hyperventilation
  9. No specific treatment exists. Continue careful monitoring.

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